GC-MS Fingerprint of Mitracarpus hirtus and Commiphora africana: Medicinal plants Used in the Treatment of Skin and Wound Infections in Bauchi Town
DOI:
https://doi.org/10.26538/tjdr/v2i4.1Keywords:
Mitracarpus hirtus, Commiphora africana, GC-MS analysis, in-silico, Wound-healingsAbstract
Purpose: Mitracarpus hirtus and Commiphora africana are two medicinal plants traditionally utilized in Bauchi town, Nigeria, for the treatment of skin and wound infections. However, the bioactive chemicals responsible for these effects have not been fully identified. On this basis, the current work employed GC-MS analysis in conjunction with computational prediction studies to investigate the presence of compounds in the aqueous extracts of these plants leaves, aiming to identify those with wound healing properties.
Methods: The Plants leaves were air-dried, pulverized into powdered form and extracted with aqueous. The extracts obtained were subjected to GC-MS analysis where the compounds identified were search both in the literature and in-silico for their wound healing characteristic. In-silico prediction for compounds' physiochemical properties, adsorption, distribution, metabolism, excretion, toxicity as well as drug-likeness properties and bioactive characteristics, including wound healing, anti-inflammatory, antioxidant, antibacterial, growth stimulation, and so on, were predicted using an online software such as activity spectra for biologically active substances (PASS) etc.
Results: The study’s findings revealed various capacities of phytochemicals in Mitracarpus hirtus and Commiphora africana extracts for wound healing. Compounds in the extracts of C. africana were detected at retention times ranging from 2.6 to 16. 5 minutes. Pyranone has the largest percentage yield at 2.06%, whereas 4-acetoxy-3-methoxystyrene has a lower yield of 0.12%. In M. hirtus extracts, components were detected after a retention duration of 5-22 minutes, with Phenol, 2,5-bis(1,1-dimethylethyl)-, having a higher presence at 2.74%. Among the compounds identified and predicted to be responsible for the wound healing properties of the plants extracts were resorcinol, undecanoic acid, and tetradecanoic acid. Quantitative Estimate of Drug-likeness (QED) for the compounds indicates that the values fall within a desirable range, with 2,5-bis(1,1-Dimethylethyl)phenol exhibiting the most favorable QED at a value of 0.68.
Conclusion: Mitracarpus hirtus and Commiphora africana showed to possess compounds with good qualities for wound healing hence confirms their used in treating skin and wounds.
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